FIGURE 18.

Selectivity of postsynaptic GABA_BR-mediated responses at perisomatic vs. dendritic targeting PV- and CCK-containing interneuron subtypes. A and B: trains of stimuli elicit robust GABA_BR-mediated postsynaptic IPSCs (traces at bottom of cell reconstructions) in PV- and CCK-BC subtypes (see insets for post hoc immunocytochemistry and membrane voltage responses including action potential firing patterns in response to hyperpolarizing and depolarizing current steps) with minimal or no response at their dendrite targeting (DTI) counterparts. Based on axonal arborization, the PV and CCK DTIs in these examples correspond to bistratified (BiC) and Schaffer-collateral associated cells, respectively (SCA). C: schematic summarizing this selectivity as described in these studies. PC, pyramidal cell. [PV cell reconstructions and traces from Booker et al. (116) with permission from Journal of Neuroscience. CCK cell reconstructions and traces from Booker et al. (115) with permission from Cerebral Cortex.]