Table 1.
Electrophysiological properties of the identified interneuron clusters
| Cluster 1 (n = 15) | Cluster 2 (n = 23) | Cluster 3 (n = 34) | Cluster 4 (n = 33) | Cluster 5 (n = 19) | Cluster 6 (n = 18) | Comparison | |
|---|---|---|---|---|---|---|---|
| Resting potential, mV | −57 ± 5 | −64 ± 7 | −70 ± 10 | −57 ± 10 | −59 ± 10 | −54 ± 6 | 3<<1,2,4,5,6 |
| Input resistance, MΩ | 116 ± 63 | 216 ± 124 | 302 ± 139 | 431 ± 193 | 401 ± 212 | 219 ± 98 | 1<<2,3,4,5,6, |
| Time constant, ms | 13 ± 8 | 46 ± 18 | 25 ± 8 | 44 ± 15 | 38 ± 13 | 22 ± 9 | 1<<3,6<<<2,4,5 |
| Sag index | 0.84 ± 0.06 | 0.79 ± 0.09 | 0.88 ± 0.06 | 0.80 ± 0.10 | 0.80 ± 0.07 | 0.71 ± 0.15 | 1,2,4,5,6 < 3 |
| Frequency at 2X threshold, Hz | 70 ± 26 | 19 ± 9 | 27 ± 10 | 17 ± 7 | 18 ± 6 | 27 ± 13 | 2,4,5<<3,6<<<1 |
| Adaption ratio at 2X threshold | 0.88 ± 0.13 | 0.64 ± 0.22 | 0.80 ± 0.12 | 0.56 ± 0.17 | 0.44 ± 0.17 | 0.46 ± 0.17 | 4,5,6 < 2<<<3 < 1 |
| 1st Spike threshold, mV | −32 ± 4 | −38 ± 3 | −34 ± 4 | −35 ± 3 | −36 ± 3 | −38 ± 4 | 2,4,5,6 < 3,1 |
| 2nd Spike threshold, mV | −32 ± 4 | −37 ± 3 | −34 ± 4 | −35 ± 3 | −35 ± 4 | −37 ± 4 | 1,2,3,4,5,6 |
| 1st Spike amplitude, mV | 47 ± 7 | 62 ± 8 | 52 ± 9 | 62 ± 6 | 48 ± 10 | 59 ± 8 | 1,3,5 < 2,4,6 |
| 2nd Spike amplitude, mV | 48 ± 8 | 61 ± 7 | 52 ± 9 | 61 ± 6 | 48 ± 10 | 60 ± 7 | 1,5 < 3<<2,4,6 |
| 1st Spike half-width, ms | 0.54 ± 0.11 | 0.74 ± 0.11 | 1.06 ± 0.20 | 0.81 ± 0.09 | 1.04 ± 0.15 | 0.72 ± 0.10 | 1<<<2,6<<4<<<3,5 |
| 2nd Spike half-width, ms | 0.54 ± 0.11 | 0.77 ± 0.12 | 1.08 ± 0.21 | 0.86 ± 0.10 | 1.12 ± 0.14 | 0.77 ± 0.10 | 1<<<2,6<<4<<<3,5 |
| 1st Time to repolarize, ms | 3.1 ± 1.2 | 4.3 ± 1.6 | 9.6 ± 4.1 | 10.8 ± 7.8 | 20.4 ± 12.7 | 11.5 ± 6.8 | 1 < 2<<<3,4,6 < 5 |
| 2nd Time to repolarize, ms | 3.1 ± 1.1 | 4.7 ± 1.5 | 9.9 ± 3.7 | 13.1 ± 7.7 | 23.2 ± 10.1 | 16.3 ± 10.0 | 1<<2<<<3,4,6<<5 |
| 1st Maximal decay slope, mV/ms | −112 ± 24 | −96 ± 17 | −55 ± 13 | −79 ± 16 | −50 ± 12 | −83 ± 14 | 1 < 2 <4,6<<<3,5 |
| 2nd Maximal decay slope, mV/ms | −113 ± 26 | −91 ± 18 | −55 ± 13 | −74 ± 15 | −46 ± 10 | −78 ± 14 | 1<<2<<4,6<<<3<<5 |
| 1st AHP amplitude, mV | 25 ± 3 | 21 ± 3 | 20 ± 3 | 19 ± 3 | 13 ± 3 | 14 ± 3 | 5,6<<<4<<2,3<<1 |
| 2nd AHP amplitude, mV | 25 ± 4 | 22 ± 3 | 21 ± 4 | 20 ± 4 | 15 ± 4 | 15 ± 3 | 5,6<<<2,3,4<<1 |
| 1st AHP half-width, ms | 29 ± 16 | 55 ± 36 | 72 ± 31 | 124 ± 76 | 85 ± 41 | 63 ± 31 | 1 < 2,3,4,5,6 |
| 2nd AHP half-width, ms | 27 ± 15 | 76 ± 47 | 69 ± 33 | 129 ± 50 | 116 ± 63 | 82 ± 32 | 1<<<2,3,6 < 4,5 |
n, Number of cells; < indicates significantly smaller with P ≤ 0.05; << indicates significantly smaller with P ≤ 0.01; <<< indicates significantly smaller with P ≤ 0.001. [From Tricoire et al. (1138) with permission from Society for Neuroscience.]