FIGURE 6.
Immune cell infiltration in tubulointerstitial areas impairs pressure natriuresis. A: salt-sensitive hypertension following l-NAME administration (SSHBP) is associated with immune cell infiltration and angiotensin positive cells in tubulointerstitial areas that are suppressed with mofetil mycophenolate (MMF) treatment. B: the severity of salt-induced hypertension is directly related to the intensity of immune cells (CD68+ and CD3+ cells) infiltration. C: pressure natriuresis is impaired in SSHBP. MMF treatment increases pressure natriuresis in l-NAME-treated rats to the values found in control rats on a high (C-HSD) and normal (C-NSD) sodium diet. SBP, systolic blood pressure; FNaE, fractional sodium excretion. [Data from Franco et al. (72).]