Figure 1.

Effects of TS on cell growth and colony formation in vitro in OVCAR-3 and A2780/CP70 human ovarian cancer cells and the cytotoxicity of TS on IOSE-364 normal ovarian cells. (a) TS inhibits cell viability of OVCAR-3, A2780/CP70 and IOSE-364 cells after 24 h. Cell viability was determined via MTS assay; (b) Cisplatin inhibits cell growth of OVCAR-3 and A2780/CP70 cells after 24 h as a control compared with TS’s inhibitory activity; (c) The estimated half-maximal inhibitory concentration (IC₅₀) of TS and cisplatin against ovarian cancer cells and/or normal ovarian cells; (d) Colony formation activity of OVCAR-3 and A2780/CP70 cells was inhibited by TS at 24 h; (e) TS exhibited extensive colony formation inhibitory effects in OVCAR-3 and A2780/CP70 cells at 24 h. The capital letters (A, B, etc.) mean extremely significant differences among different treatments (p < 0.01).