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Role of ANP in cancer. ANP, by inhibiting the conversion of GDP-Ras to GTP-Ras, inhibits MEK 1/2-ERK 1/2 kinase cascade that is activated by mitogens and VEGF signaling. ANP also inhibits STAT3 activation and WNT-mediated β-catenin signaling, thus disrupting cellular cross-talks and inhibiting proto-oncogene actions.
