Table 4.
In vitro antiprotozoal and cytotoxic activities of A. belladonna.
| Parasite | T. b. rhodesiense | T. cruzi | L. donovani | P. falciparum | Cytotoxicity |
|---|---|---|---|---|---|
| Stage | Trypamastigotes | Amastigotes | Amastigotes | IEF (Intraerythrocytic) | |
| Strain | STIB 900 (IC50 a) | Tulahuen C4 LacZ (IC50 a) | MHOM-ET-67/L82 (IC50 a) | NF54 (IC50 a) | L6 (IC50 a) |
| melarsoprol | 0.0035 b and 0.0010 c | ||||
| benznidazole | 0.660 b and 1.080 c | ||||
| miltefosine | 0.085 b and 0.091 c | ||||
| chloroquine | 0.002 b,c | ||||
| podophyllotoxin | 0.005 b and 0.007 c | ||||
| 1-O-acetylcaranine (6) | 1.97 | 35.9 | >100 | 3.21 | 14.2 |
| 3-O-acetylhamayne (24) | 1.51 | 8.3 | 17.9 | 1.14 | 1.72 |
| buphanamine (16) | 28.2 | 62.9 | >100 | 25.9 | >100 |
| crude extract | 4.67 | 34.9 | >100 | 1.17 | 34.3 |
a all values expressed as μg mL−1; b reference value to 1-O-acetylcaranine; c reference value to buphanamine, 3-O-acetylhamayne and crude extract.