Table 1.

The bidirectional P_app values of compounds 1–13 in Caco-2 cell monolayer (n = 3). ^a

Analytes	Papp AP→BL b (×10−6 cm/s)	Papp BL→AP c (×10−6 cm/s)	Efflux Ratio d	MW	Log D (pH = 7.35)
1	0	0	–	822	−8.02
2	1.55 ± 0.09	1.65 ± 0.95	1.06	646	−2.94
3	12.63 ± 0.40	14.00 ± 1.30	1.11	470	2.57
4	1.68 ± 0.13	1.78 ± 0.03	1.06	338	4.48
5	24.71 ± 2.80	30.18 ± 2.40	1.22	286	2.91
6	22.51 ± 1.00	26.44 ± 1.30	1.17	338	4.62
7	20.70 ± 1.00	23.80 ± 0.30	1.15	270	3.43
8	0	0	–	550	−0.94
9	17.80 ± 0.60	15.68 ± 0.30	0.88	256	2.95
10	0	0	–	550	−0.23
11	14.60 ± 0.10	9.35 ± 0.43	0.64	256	2.50
12	0.87 ± 0.02	0.77 ± 0.07	0.89	418	−0.48
13	0.54 ± 0.02	0.53 ± 0.03	0.98	418	0.02

^a The incubation time was up to 90 min. ^b Transport of assayed compounds from AP to BL direction. ^c Transport of assayed compounds from BL to AP direction. ^d The ratio of P_{app BL→AP} to P_{app AP→BL}.