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. 2017 Sep 5;22(9):1476. doi: 10.3390/molecules22091476

Table 1.

Minimum inhibitory concentration and minimum fungicidal concentration of compounds 4a–g and 5a–g (MIC/MFC in µg/mL).

Compound Structure Fungal Species
C.a. C.n. A.fu. A.fl. A.n. M.g. T.r. T.m.
4a graphic file with name molecules-22-01476-i001.jpg 125/250 62.5/125 i i i 31.25/31.25 31.25/31.25 31.25/31.25
4b graphic file with name molecules-22-01476-i002.jpg 250/>250 125/125 i i i 62.5/125 62.5/125 62.5/125
4c graphic file with name molecules-22-01476-i003.jpg 250/nf 125/125 i i i 62.5/62.5 62.5/62.5 31.25/31.25
4d graphic file with name molecules-22-01476-i004.jpg i 250/250 i i i 62.5/250 62.5/250 62.5/125
4e graphic file with name molecules-22-01476-i005.jpg i i i i i i i i
4f graphic file with name molecules-22-01476-i006.jpg i 250/nf i i i 250/250 250/250 125/250
4g graphic file with name molecules-22-01476-i007.jpg i 125/250 i i i 62.5/250 62.5/125 62.5/125
5a graphic file with name molecules-22-01476-i008.jpg i 125/125 i i i 125/250 125/250 125/250
5b graphic file with name molecules-22-01476-i009.jpg i 250/250 i i i i i i
5c graphic file with name molecules-22-01476-i010.jpg i 250/nf i i i 250/nf 250/nf 250/nf
5d graphic file with name molecules-22-01476-i011.jpg i i i i i i i i
5e graphic file with name molecules-22-01476-i012.jpg i i i i i i i i
5f graphic file with name molecules-22-01476-i013.jpg i i i i i i i i
5g graphic file with name molecules-22-01476-i014.jpg i i i i i i i i
Amphotericin B - 0.78 0.25 0.50 0.50 0.50 0.12 0.07 0.07
Terbinafine - 0.50 0.25 0.12 0.50 0.25 0.05 0.02 0.02

Antifungal activity was determined with the microbroth dilution assay following the CLSI guidelines; i = MIC > 250 µg/mL; nf: not fungicide up to 250 µg/mL; C.a.: Candida albicans ATCC 10231; C.n.: Cryptococcus neoformans ATCC 32264; A.n.: Aspergillus niger ATCC 9029; A.fl.: Aspergillus flavus ATCC 9170; A.fu.: Aspergillus fumigatus ATCC 26934; M.g.: Microsporum gypseum CCC 115; T.r: Trichophyton rubrum CCC 110; T.m.: Trichophyton mentagrophytes ATCC 9972.