Table 1.
AChEs and nAChRs identified in S. haematobium, S. mansoni and S. japonicum.
| Schistosome Species | AChE | nAChR | ||||
|---|---|---|---|---|---|---|
| Protein ID | Description | Protein ID | Conserved Domains/Motifs | |||
| Ligand Domain | Trans-Membrane Region | Cys-Loop | ||||
| S. haematobium | A_03825 | AChR 1alpha | AAR84357 * | √ | √ | √ |
|
KGB33661 * (XP_012793429 *) |
AChR 2beta | AAR84358 * | √ | √ | √ | |
| AChR 2beta | AAX59989 * | √ | √ | √ | ||
|
KGB33101 * (XP_012792873 *; A_04487 ~) |
nAChR beta 3 (Dbeta 3) subunit | A_01504 ~ | ||||
| A_01761 ~ | √ | |||||
|
KGB37011 * (XP_012796773 *; A_02007 ~) |
Putative nAChR alpha 9b subunit | B_00805 ~ | √ | √ | ||
| AChR beta, putative | A_05298 ~ | √ | ||||
|
AAO49838 * (AAO62355 *, AAQ14322 *) |
AChR-related | A_06497 ~ | √ | √ | ||
| ACh-gated chloride channel-1 (ShACC-1) | A_02378 ~ | √ | √ | √ | ||
| ACh-gated chloride channel-2 (ShACC-2) | A_06346 ~ | |||||
| S. mansoni |
AAQ14321 * (CCD58664 * XP_018645024 *) |
AChR alpha subunit precursor | AAR84361 * | √ | ||
| AChR non-alpha subunit precursor | AAR84362 * | √ | ||||
| ACh-gated chloride channel-1 (SmACC-1) | Smp_176310 # | √ | √ | √ | ||
| ACh-gated chloride channel-2 (SmACC-2) | Smp_142690 # | √ | √ | √ | ||
| Putative nAChR alpha 9b subunit | Smp_135040 # | |||||
| AChR-related | Smp_012000 # | √ | √ | √ | ||
| Putative nAChR subunit | Smp_101990 # | |||||
| Smp_037960 # | √ | √ | √ | |||
| Smp_157790 # | √ | √ | √ | |||
| Smp_132070 # | √ | |||||
| Smp_180570 # | √ | √ | √ | |||
| Smp_197600 # | √ | √ | ||||
| Smp_142700 # | √ | √ | ||||
| Smp_031680 # | √ | √ | √ | |||
| Smp_139330 # | √ | √ | √ | |||
| S. japonicum | Sjp_0045440 # | Putative nAChR alpha 9b subunit | Sjp_0071780 # | |||
| Sjp_0034800 # | √ | √ | √ | |||
| Neuronal AChR subunit alpha-7 | Sjp_0082390 # | √ | √ | |||
| Sjp_0070510 # | AChR-related | Sjp_0131150 # | √ | √ | √ | |
| Sjp_0036280 # | Putative nAChR subunit | Sjp_0015560 # | √ | √ | ||
| Sjp_0066940 # | √ | |||||
| ANH56887 [24] * | ACh-gated chloride channel (SjACC-1) | Sjp_0115170 # | ||||
Note: * protein ID cited from PubMed (https://www.ncbi.nlm.nih.gov/pubmed); # cited from GeneBD (http://www.genedb.org/Homepage); ~ cited from WormBase Parasite (http://parasite.wormbase.org/index.html). Amino acid sequences of all proteins listed in this Table can be found in Supplementary Materials Table S1.