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Changes of the interleaflet correlation of the CHOL densities by restricting CHOL flip-flop relative to the unrestricted bilayer (top). Schematic presentation of the effect of the interleaflet CHOL population to promote phase registration (bottom; CHOL, yellow): The interleaflet CHOL prefers to stay between registered Ld phases (red). It repels the lipids in the gray shaded part of the Lo phase (blue) and thus enhances registration.
