Table 1.

Summary of presented FFR_CT clinical trials.

Trial	Study Population	n	Intervention	Findings
NXT	Stable CAD scheduled to undergo invasive angiography	251	CCTA vs FFRCT	FFRCT had higher diagnostic accuracy than CCTA
PLATFORM	New stable CAD	584	Noninvasive stress testing vs FFRCT and ICA vs FFRCT prior to ICA	In patients randomized to an early invasive coronary angiogram for stable CAD, FFRCT was associated with a lower rate of angiography showing no obstructive CAD and safe cancellation of ICA.
RIPCORD	Stable chest pain	200	CTA vs FFRCT	FFRCT data resulted in a change in management in 36% of cases.
ADVANCE	Stable CAD	1000	CCTA Findings Reviewed	CCTA stenosis severity, importantly, even for mild CCTA stenosis, in addition to diabetes and hypertension were predictive of abnormal FFRCT.
Functional Syntax Score	Stable multivessel disease	77	Noninvasive vs invasive anatomic and functional SYNTAX score.	Functional SYNTAX score utilizing FFRCT yielded similar results to those obtained invasively and reclassified 30% of patients from the high- and intermediate- SYNTAX score to the low-risk tertile. FFRCT has good accuracy in detecting functionally significant lesions in patients with multivessel disease.

CAD = coronary artery disease. CCTA = coronary computed tomography angiography. FFR_CT = CTA-derived fractional flow reserve. ICA = invasive coronary angiography.