Table 1.
Organ and tissue biodistribution (%ID/g) and concentration (SUV) of 68Ga-DOTA-TBIA101 in healthy New Zealand White rabbits (NZR1).
| Activity Biodistribution (%ID/g) # | Activity Concentration (SUV) # | |||
|---|---|---|---|---|
| Organ or Tissue | 5 min | 60 min | 5 min | 60 min |
| Heart/Blood Pool | 0.053 ± 0.003 | 0.028 ± 0.003 *** | 0.35 ± 0.15 | 0.22 ± 0.06 |
| Liver | 0.057 ± 0.007 | 0.017 ± 0.002 *** | 0.35 ± 0.03 | 0.37 ± 0.01 |
| Spleen | 0.021 ± 0.0.03 | 0.014 ± 0.001 ** | 0.63 ± 0.01 | 0.30 ± 0.01 *** |
| Urinary Bladder | 1.32 ± 0.15 | 1.24 ± 0.002 | 9.2 ± 7.7 | 14.2 ± 1.9 |
| Kidney (L/R) | 0.16 ± 0.05 | 0.096 ± 0.035 ** | 2.5 ± 2.4 | 2.8 ± 3.1 |
| Lung (L/R) | 0.028 ± 0.002 | 0.014 ± 0.003 *** | 0.26 ± 0.04 | 0.13 ± 0.02 ** |
| Stomach | 0.004 ± 0.001 | 0.003 ± 0.001 | 0.09 ± 0.01 | 0.09 ± 0.04 |
| Quadriceps (R) | 0.011 ± 0.002 | 0.003 ± 0.001 *** | 0.24 ± 0.10 | 0.09 ± 0.02 |
| Triceps (L) | 0.009 ± 0.002 | 0.003 ± 0.001 ** | 0.24 ± 0.04 | 0.11 ± 0.01 * |
(#) Values expressed as mean (± SD) N = 3 animals. (R) right site; (L) left site; (L/R) mean value of left and right side. Two-way Student’s t-test analysis comparing SUV of 5 min with 60 min returned a p value of ≤0.1 (*), ≤0.05 (**) and ≤0.01 (***).