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(A) Schematic representation of FXa protein structural domains showing the location of the binding site and ions within the heavy chain (green cartoon) and the light chain (light blue cartoon); (B) The X-ray crystal structure of Apixaban (yellow carbons) in complex with human FXa (PDBid 2P16). Essential amino acids and binding pockets are indicated; hydrogen bonds between Apixaban and FXa residues and structural waters are shown as green dotted lines.
