Figure 1.

Average plasma concentration vs. time profiles of tegafur, 5-FU, and gimeracil after oral administration of S-1 to rats pretreated with 1% CMC-Na (Control, n = 5) or Sipjeondaebo-tang 1200 mg/kg (SDT, n = 5) as (A) a single dose or (B) multiple doses prior to S-1 administration.