Table 2.
Population pharmacokinetic parameter estimates of tegafur and its active metabolite, 5-FU.
| Parameter | Symbol | Unit | Population Mean (BSV) |
|---|---|---|---|
| Absorption rate constant for tegafur in control group | Ka,Con | 1/h | 0.296 (0.0101) |
| Absorption rate constant for tegafur in SDT pretreatment group | Ka,Pretre | 1/h | 0.197 (0.0125) |
| Formation rate constant of 5-FU precursor from gut compartment in control group | Ka,Met,Con | 1/h | 0.122 (0.308) |
| Formation rate constant of 5-FU precursor from gut compartment in SDT pretreatment group | Ka,Met,Pretre | 1/h | 0.0595 (0.655) |
| Formation rate constant of 5-FU from 5-FU precursor | KConv | 1/h | 2.88 (0.747) |
| Clearance for tegafur | CLTeg/F | L/h/kg | 0.0813 (0.00221) |
| Fraction of 5-FU clearance for 5-FU precursor formation | FMet | - | 0.342 (0.0162) |
| Clearance for 5-FU in control group | CL5FU,Con/F | L/h/kg | 3.52 (0.163) |
| Clearance for 5-FU in SDT pretreatment group | CL5FU,Pretre/F | L/h/kg | 5.93 (0.025) |
| Distribution clearance for tegafur | CLdTeg/F | L/h/kg | 0.184 (0.105) |
| Distribution clearance for 5-FU | CLd5FU/F | L/h/kg | 1.87 (0.168) |
| Central volume of distribution for tegafur | V1,Teg/F | L/kg | 0.0464 (0.729) |
| Central volume of distribution for 5-FU | V1,5FU/F | L/kg | 0.623 (0.291) |
| Peripheral volume of distribution for tegafur | V2,Teg/F | L/kg | 0.137 (0.0141) |
| Peripheral volume of distribution for 5-FU | V2,5FU/F | L/kg | 0.294 (0.184) |