Table 1.
Overview of NMR structures from M. tuberculosis proteins.
| Classification | Protein | Brief Description | PDB ID (Deposit Year) |
|---|---|---|---|
| Transport-related proteins | Rv2244 | Acyl carrier protein | 1KLP (2001) |
| Rv3250c * | Electron transport | 2KN9 (2009) | |
| Rv1739c | Sulfate transporter | 2KLN (2009) | |
| Transcription-related proteins | MT3852 | ArsR family, transcription regulator, nickel metal sensor | 2LKP (2012) |
| Rv1994c | ArsR family, transcription regulator, cadmium metal sensor | 2JSC (2013) | |
| Rv0639 * | Transcription elongation–termination factor | 2MI6 (2013) | |
| Rv2050 * | RNA polymerase binding protein | 2M4V (2013) | |
| Nucleotide-binding proteins | J113_05350 | DNA-binding response regulator | 2RV8 (2015) |
| Rv3597c * | Nucleoid-associated protein | 2KNG (2009) | |
| Ser/Thr Protein kinase-related proteins | Rv0014c * | Ser/Thr protein kinase (STPK) PknB | 2KUD, 2KUE, 2KUF, 2KUI (2010) |
| Rv1827 | Substrate of STPK PknB | 2KFU (2009) | |
| Rv0020c | Substrate of STPK PknB | 2LC0, 2LC1 (2011) | |
| Rv2175c | Substrate of STPK PknL | 2KFS (2009) | |
| Rv2234 * | Protein-tyrosine Phosphatase | 2LUO (2012) | |
| Enzymes and related proteins | Rv0733 * | Transferase, adenylate kinase | 1P4S (2003) |
| Rv1009 | Hydrolase, Resuscitation-promoting factor | 1XSF (2004) | |
| Rv1884c | Hydrolase, Resuscitation-promoting factor | 2N5Z (2015) | |
| Rv1014c * | Hydrolase, peptidyl-tRNA hydrolase | 2JRC (2007) | |
| Rv2737c | Hydrolase, endonuclease | 2L8L (2011) | |
| MT1859 | Hydrolase | 2LQJ (2012) | |
| Rv3914 | Thioredoxin | 2L59, 2L4Q (2010) | |
| Rv3198.1 | Mycothiol-dependent reductase | 2LQQ, 2LQO (2012) | |
| Siderophore-related proteins | Rv2377c * | Siderophore biosynthesis | 2KHR (2009) |
| Rv0451c | Siderophore export | 2LW3 (2012) | |
| Secreted proteins | Rv2875 | Immunogenic protein MPT70 | 1NYO (2003) |
| Rv1980c | Immunogenic protein MPT64 | 2HHI (2006) | |
| Rv3875/Mb3904 | Type VII secretion system protein | 1WA8 (2004) | |
| Rv0287/Rv0288 | Type VII secretion system protein | 2KG7 (2009) | |
| Rv0603 | Immune system | 2KGY (2009) | |
| 2LRA (2012) | |||
| Membrane proteins | Rv1761c | Membrane protein | 2K3M (2008) |
| Rv0899 | Pore-forming outer membrane protein | 2KGS, 2KGW (2009) | |
| 2KSM (2010) | |||
| 2L26 (2010) | |||
| 2LBT, 2LCA (2011) | |||
| Uncharacterized proteins | Rv2302 | Unknown function | 2A7Y (2005) |
| Rv0543c | Domain of Unknown Function DUF3349 (PF11829) | 2KVC (2010) | |
| Other proteins | Rv3418c | Chaperone | 1P82, 1P83 (2003) |
| Rv1311 | ATP synthase epsilon chain | 2LX5 (2012) | |
| Rv0431 | Vesiculogenesis and immune response regulation | 2M5Y (2013) | |
| Rv3682 * | Penicillin binding protein | 2MGV (2013) | |
| Rv1466 | [Fe-S] cluster assembly related protein | 5IRD (2016) | |
| Rv2171 | Lipoprotein | 2NC8 (2016) |
* Proteins, analyzed as potential drug targets for M. tuberculosis in this paper.