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. 2017 Sep 19;22(9):1570. doi: 10.3390/molecules22091570

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Bar graph showing the differences in the zones of inhibition, arising during the Agar Diffusion Test (ADT), of monofilament sutures coated with a 25 mg/mL totarol stock solution and different concentrations of PLGA at days 1, 10 and 15 (n = 3); (b) Representative images demonstrating a similar zone of inhibition after 15 days in all four groups. As the negative control, a PLGA-only-coated suture is shown; (c) Bar graph depicting the change in zones of inhibition around monofilament sutures sprayed with a coating solution with a concentration of 100 mg/mL totarol and varying amounts of PLGA at days 1, 10 and 15 of the ADT (n = 3); (d) Representative images of the zones of inhibition of sutures coated in the four stock solutions at day 15. As the negative control, a PLGA-only-coated suture is shown. Data are given as means with SEM. Two-way RM ANOVA followed by Tukey’s multiple comparisons test was used to identify significant differences. Asterisks (* p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001) indicate statistical significances between the diverse coatings and the control (totarol coating without PLGA). Hashes (^# p < 0.05, ^## p < 0.01, ^### p < 0.001, and ^#### p < 0.0001) indicate statistical significance between the equal coating solutions at the various time points.

(a) Bar graph showing the differences in the zones of inhibition, arising during the Agar Diffusion Test (ADT), of monofilament sutures coated with a 25 mg/mL totarol stock solution and different concentrations of PLGA at days 1, 10 and 15 (n = 3); (b) Representative images demonstrating a similar zone of inhibition after 15 days in all four groups. As the negative control, a PLGA-only-coated suture is shown; (c) Bar graph depicting the change in zones of inhibition around monofilament sutures sprayed with a coating solution with a concentration of 100 mg/mL totarol and varying amounts of PLGA at days 1, 10 and 15 of the ADT (n = 3); (d) Representative images of the zones of inhibition of sutures coated in the four stock solutions at day 15. As the negative control, a PLGA-only-coated suture is shown. Data are given as means with SEM. Two-way RM ANOVA followed by Tukey’s multiple comparisons test was used to identify significant differences. Asterisks (* p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001) indicate statistical significances between the diverse coatings and the control (totarol coating without PLGA). Hashes (^# p < 0.05, ^## p < 0.01, ^### p < 0.001, and ^#### p < 0.0001) indicate statistical significance between the equal coating solutions at the various time points.