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. 2017 Oct 20;22(10):1773. doi: 10.3390/molecules22101773

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Time revolution of baseline corrected ear thickness (µm) in terms of different SNEDDS compositions containing 10 mg/mL P. lanceolata extract in a dimethyl-benzene-induced ear edema model in mice. The administered extract dose was 150 mg/kg/day formulated in SNEDDS and administered by gavage. For the complete time period, compositions showed significant differences to the positive control. As positive control, mice were treated with dimethyl-benzene without PL-SNEDDS pre-treatment, while in the negative control group, the mice received no treatment. Values are expressed as means ± SD, n = 6. All groups receiving a treatment with PL-components 1–3, 5–7 differed significantly from their positive control group. Asterisk shown these significant differences.