Table 1.
Selection of reaction media for the synthesis of compound 5b.
Solvent | Temperature (°C) | Time (min) | Yield (%) |
---|---|---|---|
Polyethylene glycol (PEG) | 80 | 60 | 72 |
Deep eutectic solvent of cholinechloride:urea | 80 | 20 | 92 |
Ionic liquid (N-methylpyridiniumtosylate) | 120 | 75 | 62 |
Ionic liquid (triethylammonium hydrogen sulphate[Et3NH][HSO4]) | R.T. | 15 | 94 |
R.T. = Room temperature.