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. 2017 Sep 28;22(10):1628. doi: 10.3390/molecules22101628

Table 1.

Selection of reaction media for the synthesis of compound 5b.

Solvent Temperature (°C) Time (min) Yield (%)
Polyethylene glycol (PEG) 80 60 72
Deep eutectic solvent of cholinechloride:urea 80 20 92
Ionic liquid (N-methylpyridiniumtosylate) 120 75 62
Ionic liquid (triethylammonium hydrogen sulphate[Et3NH][HSO4]) R.T. 15 94

R.T. = Room temperature.