Table 1.

Hydrazones 2–11 produced mechanochemically by reacting INH and imidazolic, indazolic or indolic aldehydes. The reaction was catalyzed by p-TSA.

Aldehydes	Heterocyclic Hydrazones (6) Derived From Isoniazid
Imidazole derivatives
Indazole derivatives
Indole derivatives

^[a] Yields after washing with NaHCO₃ aqueous solution to eliminate p-TSA. According to TLC, ¹H-NMR and MS, the conversions were quantitative.