Table 5.
pKa values determined for the isonicotinoylhydrazones.
| Compound | 1a | 1b | 1c | 1d | 5 | 7 |
|---|---|---|---|---|---|---|
| pKa1 | nd a | nd a | 3.4 | 3.0 | 3.4 | 3.6 |
| pKa2 | 9.2 ± 0.1 | 7.4 ± 0.1 | 9.1 ± 0.1 | 9.5 ± 0.1 | 10.4 ± 0.1 | 11 |
| pKa3 | - | 8.9 ± 0.1 | - | >11 | - | - |
a nd for not determined.
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