Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cytotoxicity (LD50) and selectivity index (SI) for the most active hydrazones against H37Rv M.tb.
| Compound | LD50 (μM) | SI | Compound | LD50 (μM) | SI |
|---|---|---|---|---|---|
| 1a | >80 | >1600 | 5 | >80 | >727 |
| 1b | 36.3 | 74 | 6 | 129 | 143 |
| 1c | >80 | >173 | 7 | >80 | >1429 |
| 1d | >80 | >195 | 8 | >80 | >364 |
| 2 | >80 | >571 | 9 | >80 | >222 |
| 3 | >80 | >615 | 10 | 71.4 | 310 |
| 4 | >80 | >364 | 11 | 156 | 193 |
| INH | - | - |
