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. 2018 Aug 23;40(5):2547–2557. doi: 10.3892/or.2018.6667

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Hypoxia inducible factor-1α disruption reduces the invasiveness and migration potency of lentivirus-infected SMCC-7721 cells under CoCl₂-induced hypoxic conditions. (A) Cell invasiveness was measured with the Matrigel transwell assay at 24 h post treatment with ×20 magnification. (B) Scratch-wound assay for cell migration was conducted at 24 and 48 h post infection under hypoxia with ×20 magnification. Bar graphs represent the mean percentage ± standard deviation of the cell invasion/migration ratio. ***P<0.001. Ctrl, control; LV, lentivirus.