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. 2018 Sep 6;40(5):2608–2618. doi: 10.3892/or.2018.6687

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Correlation of KLF5 with the expression of FBW7 in the tissues of patients with thyroid cancer. (A) Representative IHC images of KLF5 and FBW7 in thyroid cancer tissues. (B) Correlation between the expression levels of KLF5 and FBW7 in thyroid cancer tissues. (C) Diagram presenting a summary of the results of the present study. It was proposed that the dysregulation of the tumor suppressor FBW7 reduces KLF5 degradation. Then, KLF5 promotes NF-κB p65 nuclear translocation, which in turn promotes the transcriptional levels of multiple downstream genes. FBW7, F-box/WD repeat-containing protein 7; KLF5, Kruppel-like factor 5; IHC, immunohistochemistry; NF-κB, nuclear factor-κB.