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. 2018 Sep 6;40(5):2608–2618. doi: 10.3892/or.2018.6687

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 9. — KLF5 promoted the in vivo tumor growth and metastasis of thyroid cancer cells. (A) Knockdown efficacy of KLF5 by two shRNAs was confirmed by western blotting. (B) SW579/shNC, SW579/shKLF5#1 and SW579/shKLF5#2 cells were subcutaneously injected into the right flanks of nude mice and (C) the growth curve of tumor volumes was obtained. (D) Mean weight of the tumors from the nude mice of the indicated groups. (E) Representative images of the immunohistochemistry analysis of KLF5, E-cadherin and ki67. (F) B-CPAP/NC and B-CPAP/KLF5 cells were injected intravenously into the tail vein of mice. Representative H&E staining results of lungs are presented. (G) Number of lung metastatic foci in the B-CPAP/NC and B-CPAP/KLF5 groups (5 mice per group). KLF5, Kruppel-like factor 5; shRNA/sh, short hairpin RNA; NC, negative control; H&E, hemotoxylin and eosin.