Figure 8.

Activation of the ERK1/2 signaling pathway was positively correlated with the epithelial to mesenchymal transition of tumor cells induced by tumor associated macrophages in HNSCC tissues. Hierarchical clustering analysis of CD68, CD163, Vimentin, EGFR, Slug and p-ERK1/2 in HNSCC and normal tissues. ERK1/2, extracellular signal-regulated protein kinase 1/2; CD, cluster of differentiation; EGFR, epidermal growth factor receptor; p-, phosphorylated; HNSCC, head and neck squamous cell carcinoma; HM-SCC, HNSCC with high macrophages; LM-SCC, HNSCC with low macrophages; NM, normal mucosa.