Figure 4.

Measurement of stimulated saliva secretion normalized by gland weight at (A) 2 wk, (B) 6 wk, and (C) 12 wk after 15 Gy IR. Superscripts (a, b, c) are used to group cohorts for statistical comparisons. At 2 and 6 wk, b groups are significantly different from a, and c groups are not significantly different from a or all b groups. At 12 wk, control and Ret WR and Am groups are significantly different from all 3 IR and Sal groups (mean ± SEM, n ≥ 4, ****P < 0.0001, **P < 0.01 versus IR, IP Sal, and Ret Sal, using 1-way analysis of variance with Tukey’s post hoc test for multiple comparisons). Am, amifostine; IP, intraperitoneal; IR, irradiation; Ret, retroductal; Sal, saline; WR, WR-1065.