Table 1.
Screening of OP-inhibited hBChE reactivation by 0.1 mM oximes C1, C2 and 0.05 mM oxime C3. Observed reactivation rate constants (kobs), maximal reactivation (Reactmax) obtained in time (t) are presented as the mean value of two experiments.
| OP | Oxime | kobs (min−1) | Reactmax (%) | t (h) |
|---|---|---|---|---|
| VX | C1 | - | 20 | 24 |
| C2 | 0.0064 | 60 | 24 | |
| C3 | - | 15 | 22 | |
| HI-6 | 0.0356 | 85 | 2.5 | |
| Sarin | C1 | - | 10 | 24 |
| C2 | 0.0024 | 70 | 24 | |
| C3 | 0.0010 | 65 | 22 | |
| HI-6 | 0.0113 | 98 | 24 | |
| Cyclosarin | C1 | 0.0008 | 45 | 24 |
| C2 | 0.0040 | 45 | 24 | |
| C3 | - | 35 | 22 | |
| HI-6 | 0.0260 | 70 | 24 | |
| Paraoxon | C1 | - | 10 | 24 |
| C2 | - | 30 | 24 | |
| C3 | - | 15 | 22 | |
| Obidoxime | 0.0020 | 60 | 24 | |
| Tabun | C1 | - | 10 | 24 |
| C2 | 0.0015 | 60 | 24 | |
| C3 | - | 15 | 22 | |
| K117 | 0.0095 | 67 | 24 |