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Reversible inhibition of hAChE and hBChE by the tested oximes. Dissociation inhibition constants (Ki) was evaluated from at least three experiments studied in 0.3–1.0 mM substrate ATCh concentration range.
| Oxime | Concentration (µM) |
hAChE | hBChE | hAChE/hBChE |
|---|---|---|---|---|
| Ki (µM) ± S.E. | ||||
| C1 | 100–400 | 432 ± 52 | - | 272 |
| 1–400 | - | 1.59 ± 0.06 | ||
| C2 | 100–400 | 323 ± 77 | - | 29.9 |
| 10–400 | - | 10.8 ± 0.99 | ||
| C3 | 15–100 | 3.72 ± 0.49 | - | 5.8 |
| 0.5–25 | - | 0.64 ± 0.08 | ||
