Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The binding mode of DL0410 to human P-glycoprotein. DL0410 has a good affinity of the drug binding pocket in P-gp. The Figure showed the 3D and 2D interaction. The amino acid residues of the DBP interacting with DL0410 included Leu65, Ile340, Ser344, Phe343, Gln347, Phe728, Ala729, Phe732, Phe978, and Val982 mainly via hydrogen bonding, and π-alkyl and π-π stacked interactions.
