Table 2.
A. platyceras alkaloids and their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and prolyl oligopeptidase (POP) inhibitory activity.
| Compounds | AChE (IC50, µM) a | BChE (IC50, µM) a | POP (IC50, µM) a |
|---|---|---|---|
| 1 | >1000 | >1000 | 341.0 ± 37.5 |
| 2 | 230.0 ± 21.0 | 208.9 ± 17.7 | >1000 |
| 3 | >1000 | 885.5 ± 119.5 | 337.0 ± 83.1 |
| 4 | 250.0 ± 25.0 | 530.0 ± 28.2 | >1000 |
| 5 | 223.7 ± 19.6 | >1000 | 687.0 ± 74.0 b |
| 6 | 62.3 ± 5.8 | 837.4 ± 23.0 | 277.0 ± 31.3 |
| 7 | 205.2 ± 11.7 | >1000 | n.d c |
| Galanthamine * | 1.71 ± 0.07 | 42.30 ± 1.3 | n.d. |
| Huperzine A | 0.033 ± 0.001 | >1000 | n.d. |
| Serine * | 0.063 ± 0.001 | 0.13 ± 0.004 | n.d. |
| Berberine * | n.d. | n.d. | 142.0 ± 21.5 |
| Z-Pro-prolinal * | n.d | n.d | 3.27 ± 0.02 × 10−3 |
a Results are the means ± S.E.M. of three independent replications; b reference [27]; c insufficient amounts for assay measurement; * standard; n.d. not determined.