Skip to main content
. 2017 Jul 20;22(7):1219. doi: 10.3390/molecules22071219

Table 2.

Antiviral effect of N6-substituted adenosines on the replication of the EV71 strain BrCr in RD cells.

graphic file with name molecules-22-01219-i004.jpg

No. Compound Name Substituent (R) CC50 ± SD a,b EC50 ± SD a,b SI с
1 N6-benzyladenosine
(BAPR)		 graphic file with name molecules-22-01219-i005.jpg 4.3 ± 1.6 0.28 ± 0.05 15
2 N6-isopenthenyladenosine
(iPR)		 graphic file with name molecules-22-01219-i006.jpg 6.0 ± 0.6 1.0 ± 0.2 6.0
3 N6-furfuryladenosine
(KINR)		 graphic file with name molecules-22-01219-i007.jpg 7.8 ± 3.4 1.4 ± 0.3 5.6
5 N6-(2-fluorobenzyl) adenosine graphic file with name molecules-22-01219-i008.jpg 13.3 ± 3.7 0.30 ± 0.05 44
6 N6-(3-fluorobenzyl) adenosine graphic file with name molecules-22-01219-i009.jpg 6.2 ± 1.8 0.24 ± 0.09 26
7 N6-(4-fluorobenzyl) adenosine graphic file with name molecules-22-01219-i010.jpg 2.7 ± 0.9 0.14 ± 0.05 19
8 N6-(2,6-difluorobenzyl) adenosine graphic file with name molecules-22-01219-i011.jpg >254 0.21 ± 0.01 >1210
9 N6-(2-trifluoromethylbenzyl) adenosine graphic file with name molecules-22-01219-i012.jpg >235 1.0 ± 0.1 >235
10 N6-(3-trifluoromethylbenzyl) adenosine graphic file with name molecules-22-01219-i013.jpg >235 0.068 ± 0.001 >3456
11 N6-(4-trifluoromethylbenzyl) adenosine graphic file with name molecules-22-01219-i014.jpg >235 1.0 ± 0.1 >235

a All values are in μM and are based on at least three independent dose-response curves; b On rhabdomyosarcoma (RD) cells; c Selectivity Index (SI); SI = CC50/EC50; SD, standard deviation.