Scheme 2.

Synthesis of the N-(3-trifluoroacetylindol-7-yl) acetamides 4a–g. Reagents and conditions: (i) TFAA, THF, reflux, 5 h; (ii) TFA, CH₃CN, reflux, 2 h; (iii) TFAA, reflux, 5 h.

Compound	Ar 1	Ar 2	%Yield from 3	%Yield from 2
4a	4-FC6H4-	4-FC6H4-	79	74
4b	4-MeOC6H4-	4-FC6H4-	86	80
4c	4-FC6H4-	4-MeOC6H4-	89	82
4d	4-MeOC6H4-	4-MeOC6H4-	90	84
4e	C6H5-	4-FC6H4CH=CH-	80	76
4f	4-FC6H4-	4-FC6H4CH=CH-	81	79
4g	4-MeOC6H4-	4-FC6H4CH=CH-	74	72