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. 2017 Jun 24;22(7):1051. doi: 10.3390/molecules22071051

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LC-MS profile (BPC) of a representative Fragmin^® sample (Frag-5) depolymerized by a cocktail of Heparinase I, II, III. Mass signals assignment of the main components is reported. Inset: expansion of chromatogram portion with the main unsaturated trisulfated disaccharide (ΔU_2S-A_NS,6S) eluted (panel a); extracted ion chromatograms (EIC) of m/z 594.0 attributed to saturated trisulfated disaccharide (panel b): as indicated by arrows, two positional isomers were detected. LC elution conditions: isocratic step at 2% B for 10 min, followed by a linear gradient to 60% B in 90 min and final steps of column washing and reconditioning.