ADCs |
Antibody-drug conjugates |
ALCL |
Anaplastic large-cell lymphoma |
AML |
Acute myelogenous leukemia |
BCMA |
B-cell maturation antigen |
CA9 |
Carbonic anhydrase IX |
CEA |
Carcinoembryonic antigen |
CLL |
Chronic lymphocytic leukemia |
DAR |
Drug-to-antibody ratio |
DLBCL |
Diffuse large B cell lymphoma |
DTT |
Dithiothreitol |
EDNRB |
Endothelin receptor type B |
EGFR |
Epidermal growth factor receptor |
ENPP3 |
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 |
EphA2 |
Ephrin type-A receptor 2 |
EphB2 |
Ephrin type-B receptor 2 |
FDA |
Food and Drug Administration |
GCC |
Guanyl cyclase C |
GPNMB |
Transmembrane glycoprotein NMB |
GTP |
Guanosine triphosphate |
HER2 |
Human epidermal growth factor receptor 2 |
HL |
Hodgkin’s lymphoma |
IgG |
Immunoglobulin G |
LBCL |
Large B-cell lymphoma |
LY6E |
Lymphocyte antigen 6 complex |
mAb |
Monoclonal antibody |
MBC |
Metastatic breast cancer |
MC |
Maleimidocaproyl |
MCC |
4-(N-Maleimidomethyl)cyclohexane-1-carboxylate |
MDR |
Multiple-drug resistant |
MDR1 |
Multidrug resistance protein 1 |
MM |
Multiple myeloma |
MMAE |
Monomethyl auristatin E |
MMAF |
Monomethyl auristatin F |
MTD |
Maximum tolerated dose |
MUC16 |
Mucin 16 |
NHL |
Non-Hodgkin’s lymphoma |
NSCLC |
Non-small cell lung cancer |
PEG |
Polyethylene glycol |
PK/PD |
Pharmacokinetic/pharmacodynamics |
PSMA |
Prostate specific membrane antigen |
RCC |
Renal cell carcinoma |
SAR |
Structure-activity relationship |
SCLC |
Small-cell lung cancer |
SLITRK6 |
SLIT and NTRK-like protein 6 |
SMCC |
Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate |
SPDB |
N-Succinimidyl-4-(2-pyridyldithio)butanoate |
SPP |
N-Succinimidyl 4-(2-pyridyldithio) pentanoate |
sSPDB |
Sulfo-SPDB |
STEAP1 |
Six transmembrane epithelial Antigen of prostate 1 |
TAG-72 |
Tumor-associated glycoprotein-72 |
vc |
Valine-citrulline |