Table 2.
Antimicrobial activity of 4a–m analogues, expressed as MIC100 (μg/mL).
| MIC100 (μg/mL) after 24 h | ||||
|---|---|---|---|---|
| Staphylococcus aureus | Listeria monocytogenes | Escherichia coli | Pseudomonas aeruginosa | |
| 4a | 32 | >128 | >128 | >128 |
| 4b | 128 | 128 | >128 | >128 |
| 4c | >128 | >128 | >128 | >128 |
| 4d | 4 | 8 | >128 | >128 |
| 4e | 12 | 48 | >128 | >128 |
| 4f | >128 | >128 | >128 | >128 |
| 4g | >128 | 96 | >128 | >128 |
| 4h | 4 | 8 | >128 | >128 |
| 4i | 4 | 8 | >128 | >128 |
| 4j | 16 | 16 | >128 | >128 |
| 4k | >128 | >128 | >128 | >128 |
| 4l | >32 * | >32 * | >32 * | >32 * |
| 4m | 16 | 16 | >128 | >128 |
MIC100: Minimum Inhibitory Concentration required inhibiting the growth of 100% of organisms after 24 h. The values are the geometric mean of at least three determinations. * Dissolution problems: For these compounds, the initial solution was prepared to achieve 128 μg/mL, but in the end, a maximum MIC of 32 μg/mL was reached, before observing a crystallization of the compound.