Table 1.
Summary of SARs on alkane aglycons: The solution affinity of the FimH lectin domain for and O- and C-linked alkanes and thioalkanes. Ss: steady state affinity for 5b.
| R | Cpd | Kd SPR (nM) Kd ITC (nM) HAI (µM) |
R | Cpd | Kd SPR (nM) Kd ITC (nM) HAI (µM) |
Cpd | Kd SPR (nM) Kd ITC (nM) HAI (µM) |
|---|---|---|---|---|---|---|---|
| H | 4 | 151 [4] 156 ± 45 [9] 100 |
 |
35 | 16 ± 2.4 -- -- |
106 | 25 ± 6.3 -- -- |
 |
5a | 21± 0.2 [4] -- -- |
 |
36 | 22 ± 2.7 -- -- |
107 | 22 ± 2.8 -- -- |
 |
5 | 4.3 ± 0.3 [4] 7.3 ± 1.8 [9] 6.25 |
 |
37 | 14 ± 5.0 59.5 ± 4.7 [9] 25 |
108 | 36 ± 9.0 -- -- |
 |
5b | 18 ± 0.4 Ss 17 ± 0.4 -- |
 |
38 | 14 ± 7.6 -- -- |
109 | 78 ± 5.6 -- -- |
 |
39 | 11 ± 6.1 -- -- |
110 | 32 ± 4.1 -- -- |