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. 2017 Jul 3;22(7):1101. doi: 10.3390/molecules22071101

Table 4.

The affinities of FimH for O-linked mannopyranoside sulfamides 70–75 and their C-linked mannopyranoside amide analoges 91, 92, 93 and 94, 95 and 96, as measured using SPR detection.

graphic file with name molecules-22-01101-i020.jpg

Cpd R Kd (nM) Cpd R Kd (nM) Cpd R Kd (nM) Cpd R Kd (nM)
70 graphic file with name molecules-22-01101-i021.jpg 146 ± 26 73 graphic file with name molecules-22-01101-i022.jpg 122 ± 11 91 graphic file with name molecules-22-01101-i023.jpg 372 ± 26 94 graphic file with name molecules-22-01101-i024.jpg 227 ± 54
71 graphic file with name molecules-22-01101-i025.jpg 408 ± 52 74 graphic file with name molecules-22-01101-i026.jpg 37 ± 5 92 graphic file with name molecules-22-01101-i027.jpg 397 ± 83 95 graphic file with name molecules-22-01101-i028.jpg 328 ± 63
72 graphic file with name molecules-22-01101-i029.jpg 168 ± 64 75 graphic file with name molecules-22-01101-i030.jpg 148 ± 18 93 graphic file with name molecules-22-01101-i031.jpg 105 ± 44 96 graphic file with name molecules-22-01101-i032.jpg 970 ± 382