Table 1.

The chemical structures and biological activities of DL0410 and its 50 derivatives as AChE and BuChE inhibitors.

Compound No.	R1	R2	IC50(μM)
			AChE	BuChE
1-1			0.096	1.25
1-2			0.84	2.22
1-3			1.32	5.9
1-4			0.82	2.65
1-5			0.41	1.88
1-6			3.32	4.87
1-7			49.05	36.58
1-8			0.75	0.19
1-9			1.18	0.74
1-10			0.88	2.83
1-11			0.71	2.39
1-12			0.33	1.16
1-13			1.43	1.94
1-14			1.61	13.77
1-15			0.97	0.72
1-16			2.15	1.91
1-17			3.33	6.56
1-18			9.52	>200
1-19			0.25	>200
Compound No.	R1	R2	IC50(μM)
			AChE	BuChE
2-1			75.54	20.72
2-2			74.13	66.51
2-3			0.50	3.41
2-4			3.67	19.18
2-5			0.19	1.64
2-6			12.24	>200
2-7			3.53	6.38
2-8			62.27	9.11
2-9			2.62	1.21
2-10			3.96	2.77
Compound No.	R1	R2	IC50(μM)
			AChE	BuChE
3-1			4.11	4.2
3-2			7.09	7.65
3-3			48.53	40.00
3-4			7.55	24.35
3-5			3.32	1.72
Compound No.	R1	R2	IC50(μM)
			AChE	BuChE
4-1			4.89	6.00
4-2			54.44	5.95
4-3			3.07	3.09
4-4			17.40	2.93
4-5			15.67	16.32
Compound No.	R		IC50(μM)
			AChE	BuChE
5-1	O		0.89	5.68
5-2	S		3.89	3.44
5-3			14.08	>200
Compound No.	R		IC50(μM)
			AChE	BuChE
6-1	O		0.06	0.61
6-2	S		2.03	1.71
Compound No.	Structure		IC50(μM)
			AChE	BuChE
7-1			31.74	13.78
7-2			17.13	1.55
7-3			34.09	0.06
7-4			18.53	>200
7-5			3.35	0.20
7-6			0.03	0.44
7-7			1.42	4.79