Table 2.

Clinical investigations on healthy subjects (participants receiving no other medicine) supplemented with resveratrol.

Aim (To Study the Effect of Resveratrol)	No. of Treated Subjects (Males, Females or Both)	Dose of Resveratrol	Duration of Treatment in Days	Important Findings	Reference
On metabolic profile	32 (Both)	300 or 1000 mg	84	Suppressed levels of fasting glucose (by 1.67 ± 1.51 mg/dL at 300 mg dose) and bilirubin	[27]
On metabolic profile	24 (Males)	500 mg	28	Non-significant change in the markers of obesity	[6]
On metabolic profile	16 (Males)	150 mg	28	Non-significant effect on aerobic or anaerobic capacity	[28]
On metabolic profile	11 (Males)	150 mg	30	Enhanced oxidative phosphorylation and reduced postprandial energy expenditure and adipose tissue lipolysis	[29]
On metabolic profile and insulin sensitivity	29 (Females)	75 mg	84	Non-significant effect on metabolic rate or the insulin sensitivity	[30]
On energy expenditure and substrate metabolism	18 (Both)	200 mg	3	Significantly improved fasting and postprandial energy expenditure	[31]
On postprandial incretin hormone levels	10 (Males)	150 mg	30	Significant suppression of postprandial glucagon response	[32]
On adipose tissue morphology	11 (Males)	150 mg	30	Significantly reduced adipocyte size as well as ameliorated insulin sensitivity	[33]
On markers of oxidative and inflammatory stress.	20 (Both)	40 mg	42	Diminished levels of oxidative stress and inflammation biomarkers	[34]
On markers of oxidative and inflammatory stress.	10 (Both)	100 mg	Single dose	Suppressed the increase in oxidative stress, lipopolysaccharide and LBP concentrations	[35]
On markers of oxidative stress in obese patients.	32 (Both)	150 mg	Single dose	Significantly higher antioxidant effect of RSV triphosphate (RTP) and grape extract than RSV	[36]
On inflammation and oxidative stress markers in smokers.	50 (Both)	500 mg	90	Diminished levels of C-reactive protein and triglycerides, and increased total antioxidant levels	[37]
On human mononuclear cells upon bacterial stimulation.	10 (Males)	5000 mg	Single dose	Increase in TNF-levels while IL-10 levels were decreased.	[38]
On cerebral blood flow and cognitive performance	9 (Males)	250 mg and 500 mg	Single dose	Increased cerebral blood flow	[39]
On flow-mediated dilation (FMD) and cognitive performance.	28 (Both)	75 mg	42	No adverse side effects	[40]
On flow-mediated dilation (FMD) and cognitive performance	6 (Males)	250 mg	Single dose	Significant increase in FMD	[41]
On cognitive performance	46 (Both)	200 mg	182	Significantly improved memory retention	[42]
On endothelial response and vascular markers.	41 (Both)	400 mg	30	Protection against atherosclerosis	[43]
On systemic sex hormone levels	40 (Females)	500 mg	84	Significant increase in sex-hormone binding globulin	[44]
Of administered form on bioavailability	15 (Both)	40 mg	Single dose	Ameliorated absorption in dry powder form	[45]
Of gut microbiota on metabolism of resveratrol	22 (Both)	0.5 mg/kg	Single dose	Variable metabolism of resveratrol among individuals	[46]