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. 2017 Jul 28;22(8):1265. doi: 10.3390/molecules22081265

Table 1.

Inhibitory activities of novel (±)-1·HCl and reference compounds ((±)-HupY·HCl, THA, 7-MEOTA and 6-chlorotacrine) for hAChE and hBChE expressed as IC50 values.

Compound IC50 ± SEM (µM) a Selectiviy for hAChE b
hAChE hBChE
(±)-1·HCl 2.63 ± 0.36 3.76 ± 0.12 1.43
(±)-HupY·HCl 0.00164 ± 0.00014 0.358 ± 0.025 218.29
THA 0.32 ± 0.013 c 0.08 ± 0.001 c 0.68
7-MEOTA 10.00 ± 0.974 c 17.56 ± 0.795 c 1.76
6-chlorotacrine 0.02 ± 0.001 c 1.78 ± 0.097 c 100.68

a Results are expressed as the mean of at least three experiments; b selectivity for hAChE is determined as ratio IC50(hBChE)/IC50(hAChE); c data taken from Ref. [45,46,47,48].