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. 2017 Jul 14;22(7):1175. doi: 10.3390/molecules22071175

Figure 5.

Figure 5

Evodiamine inhibited HepG2 cell proliferation through a WWOX-dependent pathway. (A) HepG2 cells were treated with scramble siRNA or siRNA targeted to WWOX (siWWOX). The knockdown of WWOX was evaluated using Western blot analysis; (B) After the transfection of scramble siRNA or siWWOX for 48 h, the cells were treated with 10 μM evodiamine for 24 h. The cell viability was determined by MTT assay. The data are expressed as means ± S.E.M. and obtained from four independent experiments. *** p < 0.001 as compared with the indicated groups.