Table 1.
RNA expression profiles.
| (A) Enterococcus caccae Genes Upregulated in Response to Apigenin | |||
|---|---|---|---|
| Gene | Description | Fold ▲ | Description of Function |
| UC7_RS11115 | hypothetical protein | 7.0 | Unknown |
| UC7_RS15590 | hypothetical protein | 5.9 | Unknown |
| UC7_RS11110 | glycerophosphoryl diester phosphodiesterase | 2.9 | Phospholipid metabolism |
| UC7_RS11955 | tyrosine recombinase XerC | 2.8 | DNA dimer resolution |
| UC7_RS11545 | hypothetical protein | 2.7 | Unknown |
| UC7_RS16330 | acyl carrier protein | 2.6 | Fatty acid biosynthesis |
| UC7_RS16340 | MarR family transcriptional regulator | 2.5 | Stress response |
| UC7_RS13900 | glycine cleavage system protein H | 2.4 | Glycine degradation |
| UC7_RS11945 | ATP-dependent protease ATPase subunit HslU | 2.3 | Protein quality control |
| UC7_RS16335 | 3-oxoacyl-ACP synthase III | 2.3 | Type II fatty acid synthesis |
| UC7_RS13125 | hypothetical protein | 2.2 | Unknown |
| UC7_RS11950 | ATP-dependent protease subunit HslV | 2.2 | Protein quality control |
| UC7_RS14535 | chaperonin | 2.2 | Protein folding |
| UC7_RS11290 | phosphoglycerol transferase | 2.1 | Lipoteichoic acid biosynthesis |
| UC7_RS15845 | hypothetical protein | 2.1 | Unknown |
| UC7_RS13905 | spx/MgsR family transcriptional regulator | 2.1 | Stress response |
| UC7_RS11940 | GTP-sensing transcriptional pleiotropic repressor CodY | 2.1 | Transcriptional regulation |
| UC7_RS13910 | cell cycle protein FtsW | 2.1 | Cell division |
| UC7_RS12345 | CBS domain-containing protein | 2.1 | metabolism |
| UC7_RS13095 | N5-carboxyaminoimidazole ribonucleotide mutase | 2.1 | Purine synthesis |
| UC7_RS15130 | acyltransferase | 2.1 | Peptidoglycan synthesis |
| UC7_RS12825 | phenazine biosynthesis protein PhzF | 2.0 | Phenazine biosynthesis |
| UC7_RS13565 | hypothetical protein | 2.0 | Unknown |
| UC7_RS15200 | excinuclease ABC subunit B | 2.0 | DNA repair |
| UC7_RS13270 | neutral zinc metallopeptidase | 1.9 | Extracellular metabolism |
| UC7_RS14315 | magnesium-transporting ATPase | 1.9 | Magnesium transportation |
| UC7_RS13560 | diaminopimelate dehydrogenase | 1.8 | Lysine biosynthesis |
| UC7_RS11285 | hypothetical protein | 1.8 | Unknown |
| UC7_RS12620 | undecaprenyl pyrophosphate synthase | 1.8 | Peptidoglycan biosynthesis |
| UC7_RS15260 | hypothetical protein | 1.7 | Unknown |
| UC7_RS16325 | enoyl-ACP reductase II | 1.7 | Fatty acid biosynthesis |
| UC7_RS12170 | hypothetical protein | 1.7 | Unknown |
| UC7_RS11935 | aldolase 1 epimerase LacX | 1.7 | Carbohydrate metabolism |
| UC7_RS11340 | cold-shock protein | 1.7 | Stress response |
| UC7_RS15195 | UvrABC system protein A | 1.7 | DNA repair |
| UC7_RS13110 | hypothetical protein | 1.7 | Unknown |
| UC7_RS13815 | hypothetical protein | 1.7 | Unknown |
| UC7_RS13990 | hypothetical protein | 1.7 | Unknown |
| UC7_RS13115 | N-acetylmuramoyl-l-alanine amidase | 1.7 | Cell separation |
| UC7_RS16345 | hypothetical protein | 1.7 | Unknown |
| UC7_RS12340 | 2_3_4_5-tetrahydropyridine-2_6-dicarboxylate N-acetyltransferase | 1.7 | Lysine biosynthesis |
| UC7_RS13365 | NrdR family transcriptional regulator | 1.7 | DNA synthesis and repair |
| UC7_RS14530 | molecular chaperone GroEL | 1.7 | Protein folding |
| UC7_RS14300 | GNAT family acetyltransferase | 1.6 | Transcriptional regulation |
| UC7_RS16190 | penicillin-binding protein 2B | 1.6 | Cell wall synthesis |
| UC7_RS13090 | phosphoribosylaminoimidazole carboxylase ATPase subunit | 1.6 | Purine and pyrimidine ribonucleotide biosynthesis |
| UC7_RS15255 | hypothetical protein | 1.6 | Unknown |
| UC7_RS13120 | hypothetical protein | 1.6 | Unknown |
| UC7_RS13335 | chaperone protein ClpB | 1.6 | Protein folding |
| UC7_RS14685 | DNA-binding response regulator | 1.6 | Transcriptional regulation |
| UC7_RS11985 | S26 family signal peptidase | 1.6 | Protein maturation |
| UC7_RS12190 | elongation factor Tu | 1.6 | Protein synthesis |
| UC7_RS15900 | d-alanine-poly(phosphoribitol) ligase subunit 2 | 1.6 | Cell wall/membrane metabolism |
| UC7_RS16320 | malonyl CoA-ACP transacylase | 1.5 | Fatty acid and polyketide synthesis |
| UC7_RS13160 | penicillin-binding protein | 1.5 | Cell wall synthesis |
| UC7_RS15715 | 50S ribosomal protein L10 | 1.5 | Protein translation |
| UC7_RS15600 | phosphocarrier protein HPr | 1.5 | Carbohydrate phosphorylation |
| UC7_RS13265 | hypothetical protein | 1.5 | Unknown |
| UC7_RS15250 | hypothetical protein | 1.5 | Unknown |
| UC7_RS12410 | signal peptidase I | 1.5 | Protein maturation |
| (B) Enterococcus caccae Genes Downregulated in Response to Apigenin | |||
| Gene | Description | Fold ▼ | Description of Function |
| UC7_RS16160 | hypothetical protein | 2.4 | Unknown |
| UC7_RS16570 | hypothetical protein | 2.2 | Unknown |
| UC7_RS14780 | hypothetical protein | 2.0 | Unknown |
| UC7_RS13490 | Lsa family ABC-F type ribosomal protection protein | 2.0 | Ribosomal protection |
| UC7_RS14785 | hypothetical protein | 1.9 | Unknown |
| UC7_RS11535 | hypothetical protein | 1.9 | Unknown |
| UC7_RS15700 | general stress protein GlsB | 1.9 | Stress response |
| UC7_RS14775 | hypothetical protein | 1.8 | Unknown |
| UC7_RS15645 | hypothetical protein | 1.8 | Unknown |
| UC7_RS16575 | hypothetical protein | 1.8 | Unknown |
| UC7_RS16225 | WxL domain surface protein | 1.7 | Surface protein binding |
| UC7_RS13920 | hypothetical protein | 1.7 | Unknown |
| UC7_RS15555 | MocD family protein | 1.7 | Catabolism of mannopine |
| UC7_RS13450 | hypothetical protein | 1.7 | Unknown |
| UC7_RS16165 | hypothetical protein | 1.7 | Unknown |
| UC7_RS13865 | SufS family cysteine desulfurase | 1.6 | Fe-S protein biosynthesis |
| UC7_RS13860 | iron-sulfur cluster assembly scaffold protein | 1.6 | Iron-sulfur cluster formation |
| UC7_RS14795 | deoxycytidine triphosphate deaminase | 1.6 | Nucleotide metabolism |
| UC7_RS13855 | FeS assembly protein SufB | 1.6 | Iron-sulfur cluster formation |
| UC7_RS13455 | hypothetical protein | 1.6 | Unknown |
| UC7_RS11040 | hypothetical protein | 1.6 | Unknown |
| UC7_RS12130 | hypothetical protein | 1.6 | Unknown |
| UC7_RS13465 | hypothetical protein | 1.5 | Unknown |
| UC7_RS12125 | hypothetical protein | 1.5 | Unknown |
| UC7_RS14270 | ATP synthase subunit C | 1.5 | ATP synthesis |
| UC7_RS16230 | hypothetical protein | 1.5 | Unknown |
| UC7_RS16220 | hypothetical protein | 1.5 | Unknown |
| UC7_RS11885 | cardiolipin synthase | 1.5 | Phospholipid biosynthesis |
| UC7_RS14805 | ATP-grasp domain-containing protein | 1.5 | metabolism |
| UC7_RS15830 | thioredoxin-disulfide reductase | 1.5 | Redox regulation |