Table 1.

Cytotoxic effects of compounds 1–9 and cisplatin on A549, C6, and NIH/3T3 cells.

Compound	IC50 Values for Cell Lines (mM)			SI Values 1
	NIH/3T3	A549	C6	A549	C6
1	0.308 ± 0.037	>1.234	0.128 ± 0.027	24.959	240.625
2	1.413 ± 0.094	>1.432	>1.432	98.673	98.673
3	1.369 ± 0.074	1.369 ± 0.058	0.507 ± 0.049	100	270.018
4	1.285 ± 0.090	>1.285	>1.285	100	100
5	>1.066	>1.066	>1.066	100	100
6	>1.211	>1.211	>1.211	100	100
7	0.100 ± 0.011	>1.166	>1.166	8.576	8.576
8	>1.104	0.125 ± 0.020	0.137 ± 0.015	883.200	805.839
9	0.888 ± 0.029	0.349 ± 0.046	0.157 ± 0.016	254.441	565.605
Cisplatin	>1.166	0.140 ± 0.030	0.103 ± 0.026	1190	1617.476

¹ SI values were calculated from the equation as follows: $\mathrm{SI}=\frac{{\mathrm{IC}}_{50}\mathrm{value}\mathrm{for}\mathrm{NIH}/3\mathrm{T}3\mathrm{cell}\mathrm{line}}{{\mathrm{IC}}_{50}\mathrm{value}\mathrm{for}\mathrm{A}549\mathrm{or}\mathrm{C}6\mathrm{cell}\mathrm{line}}\times 100$.