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The effect of DOX, Cu-DOX, Zn-DOX, Co-DOX, Ni-DOX, Fe-DOX, Mn-DOX and Mg-DOX on cell proliferation of MCF-7 cells. The cells were incubated with 0.5 µM, 0.1 µM, 0.05 µM and 0.01 µM DOX and Metal-DOX complexes for 2 h (a), 4 h (b) and 24 h (c). Mean values from five independent experiments ± SD are shown. Significant alterations are expressed relative to DOX—controls and marked with crosses (#). Statistical significance was considered if # p < 0.05.
