Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 17;22(7):1198. doi: 10.3390/molecules22071198

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 1 — Reagents and conditions: (i) anhydr. DMF, DIPEA, microwave, 15 min., 130 °C, 5 bar; (ii) anhydr. THF, absol. EtOH, Pd-C, RT, 4 h; (iii) CDI, anhydr. THF, DMAP, microwave, 15 min., 130 °C, 7 bar; (iv) CF₃COOH, CH₂Cl₂, RT, 2 h; (v) anhydr. DMF, Et₃N, 2-Br-4’-chloroacetophenone, 0 °C → RT, 2 h; (vi) TMSN₃, TBAF, 125 °C, 24 h; (vii) CF₃COOH, CH₂Cl₂, RT, 2 h; (viii) anhydr. DMF, Et3N, 2-Br-4’-chloroacetophenone, 2 h, 0 °C → RT.