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The proposed forming mechanisms of protein S-nitrosylation and S-sulfhydration through the acid–base motif. (A) The proposed mechanism of S-nitrosylation in the acid–base motif. (B) The proposed mechanism for S-sulfhydration. The regulatory mechanism for S-nitrosylation and S-sulfhydration is assisted by neighboring acid (histidine) and base (aspartic acid) amino acids.
