Table 2.
Effects of compound 1–7 (10 μM) on doxorubicin (DOX) cytotoxicity in K562 cells and K562/A02cells. Half maximal inhibitory concentration(IC 50) values (μM) for DOX were calculated and the reversal folds (RF) were evaluated. Data were expressed as means ± SD of five independent experiments.
| Compounds | IC50 (K562) | IC50 (K562/A02) | RF (K562/A02) |
|---|---|---|---|
| DOX | 0.66 ± 0.12 | 19.2 ± 0.31 | |
| DOX + Verapamil | 0.58 ± 0.23 | 2.12 ± 0.19 | 9.06 |
| DOX + 1 | 0.67 ± 0.11 | 5.18 ± 0.17 | 3.71 |
| DOX + 2 | 0.62 ± 0.08 | 4.14 ± 0.33 | 4.64 |
| DOX + 3 | 0.69 ± 0.10 | 3.74 ± 0.12 | 5.13 |
| DOX + 4 | 0.70 ± 0.24 | 3.04 ± 0.33 | 4.75 |
| DOX + 5 | 0.65 ± 0.16 | 5.14 ± 0.12 | 3.74 |
| DOX + 6 | 0.68 ± 0.12 | 2.31 ± 0.10 | 8.31 |
| DOX + 7 | 0.60 ± 0.22 | 3.93 ± 0.26 | 5.94 |