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. 2017 Aug 18;22(8):1367. doi: 10.3390/molecules22081367

Table 1.

Optimization of reaction conditions a.

graphic file with name molecules-22-01367-i001.jpg

Entry Catalyst Amount Yield (%) b,c
1 CuI 1.0 mol % 43
2 CuI 2.0 mol % 71
3 CuI 3.0 mol % 90
4 CuI 4.0 mol % 90
5 CuBr 3.0 mol % 56
6 CuCl 3.0 mol % 67
7 CuCl2 3.0 mol % 72
8 Cu(OAc)2 3.0 mol % 46
9 CuO 3.0 mol % 61
10 nano-CuO 3.0 mol % 65
11 I2 3.0 mol % 69
12 - - Traces

a Reaction conditions: 1a (0.25 mmol), 2a (2.0 equiv.), DMSO (3.0 equiv.) under MW irradiation; b Isolated yield; c This reaction works similarly in 0.125 mmol scale with less reproducibility.