Fig. 3.

Pro-fibrotic mediators in bleomycin model following STAT3 inhibition

Total mRNA was isolated from skin biopsies from PBS-treated mice exposed to DMSO or C188-9 and bleomycin treated mice exposed to DMSO or C188-9. RNA transcripts were determined for Col1α1 (A), α-SMA (B), TGF-β (C), CTGF (D), IL-6 (E), Fibronectin (F) and Cad11 (G). Transcripts were measured in parallel with 18S rRNA and values are presented as mean of fold change transcripts ± s.e.m., n = 10–12 mice per group (*P ≤ 0.05 PBS DMSO vs BLM DMSO; **P ≤ 0.05 BLM DMSO vs BLM C188-9).